Heat the oven to 300°F and line a rimmed baking sheet with parchment paper.
Scoop the seeds out of the pumpkin, rinse off the pulp in a colander, and pat the seeds completely dry with a clean kitchen towel.
In a large bowl, toss the dry seeds with the olive oil, smoked paprika, garlic powder, sea salt and pepper until evenly coated.
Spread the seeds in a single layer on the prepared baking sheet without crowding them.
Bake for 40-45 minutes, stirring every 15 minutes, until the seeds are golden and crisp.
Let the seeds cool on the baking sheet for 10 minutes — they crisp up as they cool. Taste, add more salt if needed, then store in an airtight jar for up to 1 week.