Heat oven to 425°F and line a large rimmed baking sheet with parchment paper. Toss the broccoli with 1 tbsp olive oil, 1/4 tsp salt and a pinch of black pepper, spread it in a single layer, and roast for 8 minutes.
Meanwhile, whisk the honey, soy sauce, remaining 1 tbsp olive oil, garlic, lemon zest, lemon juice and red pepper flakes together in a small bowl.
Pull the sheet from the oven and push the broccoli to the edges. Pat the salmon dry, set the fillets in the center, and season with the remaining 1/4 tsp salt.
Brush the salmon generously with the glaze. Roast for 10-12 minutes, until the salmon flakes easily with a fork and reaches 145°F and the broccoli edges are crisp.
Spoon the warm pan glaze over the salmon, add lemon wedges, and serve.